|
Symbol Name ID |
Kdm6a
lysine (K)-specific demethylase 6A MGI:1095419 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Hemolytic anemia |
Acute lymphoblastic leukemia |
T-cell acute lymphoblastic leukemias |
Autoimmune thrombocytopenia |
Lymphoma |
| Disease(s) Associated with KDM6A | |||||
| acute lymphoblastic leukemia | |||||
| Kabuki syndrome |
| Mouse Phenotypes | hematopoietic system phenotype |
enlarged spleen |
increased spleen weight |
decreased common myeloid progenitor cell number |
abnormal erythropoiesis |
extramedullary hematopoiesis |
anemia |
abnormal bone marrow cell morphology/development |
increased granulocyte monocyte progenitor cell number |
abnormal megakaryocyte morphology |
decreased erythroid progenitor cell number |
decreased erythrocyte cell number |
decreased hemoglobin content |
decreased mean corpuscular volume |
increased nucleated erythrocyte cell number |
abnormal granulocyte morphology |
increased neutrophil cell number |
increased granulocyte number |
thrombocytopenia |
increased B cell number |
increased monocyte cell number |
decreased leukocyte cell number |
increased myeloid cell number |
increased hematopoietic stem cell number |
decreased megakaryocyte-erythroid progenitor cell number |
abnormal hematopoietic stem cell physiology |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||
| Kdm6atm1.2Kaig/Kdm6atm1.2Kaig | |||||||||||||||||||||||||||
| Kdm6atm1.1Afst/Kdm6atm1.1Afst Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ (conditional) |
|||||||||||||||||||||||||||
| Kdm6atm1Cdcn/Kdm6atm1Cdcn Tg(CAG-cre/Esr1*)5Amc/0 (conditional) |
|||||||||||||||||||||||||||
| Kdm6atm1.1Afst/Y Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ (conditional) |
* | ||||||||||||||||||||||||||
| Kdm6atm1Cdcn/Y Tg(CAG-cre/Esr1*)5Amc/0 (conditional) |
|||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||
Analysis Tools